Product Details
| Product Name:
CCT244747 |
CAS No.:
1404095-34-6 |
| Purity:
99.17% |
Supply Ability:
10g |
| Release date:
2025/09/30 |
Product Introduction
Bioactivity
| Name | CCT244747 |
| Description | CCT244747 is a potent and highly selective CHK1 inhibitor that is orally active, ATP-competitive, and cytotoxic, abrogating drug-induced S and G2 blockade and inducing apoptosis in multiple tumor cell lines. |
| In vitro | Methods: HT29 and SW620 colon cancer cell lines were treated with CCT244747 (0.01, 0.05, 0.1, 0.5, 1, 2, 5 μM) to characterize its effects on drug-induced changes in CHK1 and cell cycle biomarkers.
Results CCT244747 inhibited SN38- and gemcitabine-induced CHK1 activity in tumor cells, and this was associated with abrogation of cell cycle arrest, induction of DNA damage, and apoptosis. [4] |
| In vivo | Methods: Athymic mice bearing SW620 human colon cancer xenografts were treated with CCT244747 (100-300 mg/kg, oral) followed by gemcitabine (60 mg/kg, intravenous) 1 hour later to further analyze the pharmacodynamics of CCT244747.
Results: A single oral dose of CCT244747 (100-300 mg/kg) maintained inhibition of gemcitabine-induced pS296 CHK1 in HT29 colon tumor xenografts for up to 24 hours. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (97.93 mM), Sonication is recommended.
|
| Keywords | Chk1 | CCT-244747 | CCT244747 |
| Inhibitors Related | Rabusertib | CCT245737 | BML-277 | Prexasertib | PD0166285 | CHK1-IN-3 | CHK1-IN-4 hydrochloride | A-443654 | Prexasertib dihydrochloride | BX795 | ANI-7 | Baricitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States