CGS 15435 NEW
| Price | $83 | $201 | $273 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-24 |
Product Details
| Product Name: CGS 15435 | CAS No.: 95853-92-2 |
| Purity: 99.63% | Supply Ability: 10g |
| Release date: 2025/10/24 |
Product Introduction
Bioactivity
| Name | CGS 15435 |
| Description | CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase. |
| In vitro | CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).[1] |
| In vivo | The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.57 mg/mL (10 mM), Sonication is recommended. |
| Keywords | TXA2R | TXA2 | CGS-15435 | CGS15435 | CGS 15435 |
| Inhibitors Related | Rosiglitazone | Retinoic acid | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin | Cloxiquine |
| Related Compound Libraries | Nuclear Receptor Compound Library | DNA Damage & Repair Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Obesity Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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