Chst15-IN-1 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: Chst15-IN-1 | CAS No.: 2158198-77-5 |
| Supply Ability: 10g | Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | Chst15-IN-1 |
| Description | Chst15-IN-1 is a powerful, reversible, covalent inhibitor of the Chst15 enzyme. It effectively suppresses the sulfation levels of chondroitin sulfate-E (CS-E) and other closely related sulfotransferases responsible for glycosaminoglycans (GAGs) synthesis. Acting as a selective sulfotransferase inhibitor, Chst15-IN-1 can attenuate the inhibitory actions of chondroitin sulfate proteoglycans (CSPGs), making it a promising candidate for enhancing neuronal repair. |
| In vitro | Chst15-IN-1, at concentrations of 25 μM for 24 hours in Neu7 astrocytes, demonstrates selectivity for sulfotransferases compared to a wide range of cysteine-reactive proteins. Furthermore, Chst15-IN-1 exhibits a significant dose-dependent reduction in cell-surface CS-E expression in Neu7 astrocytes at both 10 and 25 μM concentrations[1]. |
| In vivo | Chst15-IN-1 (3.0 mg/kg; i.v.) shows a moderate clearance rate of 21 mL/min/kg, a moderate volume of distribution at 0.97 L/kg, and a short terminal half-life of 1.6 hours in rats during pharmacokinetic analysis, summarizing its efficacy and disposition within the tested animal model[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Chst-15-IN-1 | Chst15IN1 | Chst15 IN 1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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