Ciclopirox NEW
| Price | $30 | $43 | $61 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-21 |
Product Details
| Product Name: Ciclopirox | CAS No.: 29342-05-0 |
| Purity: 99.41% | Supply Ability: 10g |
| Release date: 2025/06/21 |
Product Introduction
Bioactivity
| Name | Ciclopirox |
| Description | Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, the organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX). |
| In vivo | Ciclopirox induces the activity of HIF-1-mediated reporter genes and the expression of endogenous HIF-1 target genes, including increased levels of mRNA expression, transcription, and vascular endothelial growth factor protein. It exerts a dose-dependent inhibitory effect on the growth of Candida albicans yeast and filamentous cells. Ciclopirox prevents mitochondrial damage induced by H2O2 by maintaining mitochondrial transmembrane potential. In adenocarcinoma SK-HEP-1 cells, Ciclopirox decreases MTT reduction (a marker of mitochondrial function) and completely blocks the release of lactate dehydrogenase (a marker of cell death) stimulated by hydrogen peroxide. In astrocytes treated with SIN-1 under glucose deprivation, Ciclopirox increases and maintains high levels of MTP, also preventing the depletion of adenosine triphosphate. Furthermore, Ciclopirox effectively inhibits the opening of mitochondrial permeability transition pores induced by hydrogen peroxide and protects astrocytes from peroxynitrite toxicity by mitigating mitochondrial dysfunction caused by nitrite. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
| Solubility Information | Ethanol : 20.7 mg/mL (99.87 mM), Sonication is recommended. DMSO : 50 mg/mL (241.23 mM), Sonication is recommended. |
| Keywords | Na+/K+-ATPase | Inhibitor | inhibit | Fungal | Ferroptosis | Ciclopirox | Bacterial | Autophagy |
| Inhibitors Related | Neomycin sulfate | Stavudine | Cysteamine hydrochloride | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Doxycycline | Paeonol | Naringin | Dimethyl sulfoxide | Alginic acid |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Fungal Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $/ |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2025-04-29 | |
| $0.00/1KG |
VIP3Y
|
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-11-04 | |
| $0.00/25KG |
VIP6Y
|
Hebei Mujin Biotechnology Co.,Ltd
|
2023-10-16 | |
| $0.00/1KG |
VIP5Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2023-01-10 | |
| $20.00/1KG |
Qiuxian Baitai New Material Co., LTD
|
2021-11-05 | ||
| $1.10/1g |
VIP5Y
|
Dideu Industries Group Limited
|
2021-07-19 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $0.00/1Kg |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-01-02 | |
| $7.00/1kg |
VIP7Y
|
Career Henan Chemical Co
|
2018-12-16 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY