Product Details
| Product Name:
Closthioamide |
CAS No.:
1227367-59-0 |
| Supply Ability:
10g |
Release date:
2025/08/22 |
Product Introduction
Bioactivity
| Name | Closthioamide |
| Description | Closthioamide is a potent inhibitor of bacterial DNA gyrase and is highly effective against MRSA, Ec, VRE, and Mv [MICs: 0.58 μM, 9.00 μM, 0.58 μM, and 72.03 μM, respectively]. |
| In vitro | Closthioamide is isolated from the strictly anaerobic bacterium Clostridium cellulolyticum, and belongs to a new class of natural products [1]. Closthioamide is highly active against a pathogenic, methicillin-resistant Staphylococcus aureus (MRSA) strain with a minimum inhibitory concentration (MIC) of 0.4 μg/mL-1 (0.58 μM). Closthioamide is even active against vancomycin-resistant Enterococcus faecalis (VRE) with the same low MIC value and is thus significantly more potent against these bacteria than ciprofloxacin, the standard drug used against VRE, with remarkable strain selectivity. Closthioamide shows moderate antiproliferative and cytotoxic effects [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Closthioamide | Bacterial DNA gyrase |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Rifampicin | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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$2180.00/50mg |
VIP4Y
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TargetMol Chemicals Inc.
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2025-08-21 |
United States