Product Details
| Product Name:
CMC2.24 |
CAS No.:
1255639-43-0 |
| Supply Ability:
10g |
Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | CMC2.24 |
| Description | CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3]. |
| In vitro | CMC2.24 (0-60 μM; 24 hours) inhibits pancreatic cancer growth in vitro by reducing STAT3Ser727 phosphorylation levels, inducing mitochondrial reactive oxygen species, and promoting intrinsic apoptosis and mitochondrial cell death in pancreatic cancer cells[1]. |
| In vivo | CMC2.24 (50 mg/kg; p.o.; five times per week for 17 days) inhibits pancreatic cancer xenograft growth and human PC through a potent cytokinetic effect, and disrupts the ERK signaling pathway in PC cells and xenografts[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble or slightly soluble)
|
| Keywords | CMC-2.24 | CMC2.24 |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Doxycycline | Formamide | Dimethyl phthalate | Daraxonrasib | Alginic acid | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States