CZC-54252 hydrochloride NEW
| Price | $44 | $69 | $137 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: CZC-54252 hydrochloride | CAS No.: 1784253-05-9 |
| Purity: 99.28% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | CZC-54252 hydrochloride |
| Description | CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM. |
| In vitro | CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (55.41 mM), Sonication and heating to 60℃ are recommended. |
| Keywords | neuroprotective | neuronal | LRRK2-G2019S | LRRK2 | Leucine-rich repeat kinase 2 | injury | Inhibitor | inhibit | G2019S LRRK2 | CZC-54252 Hydrochloride | CZC54252 hydrochloride | CZC54252 Hydrochloride | CZC-54252 | CZC54252 | CZC 54252 hydrochloride | CZC 54252 Hydrochloride | CZC 54252 |
| Inhibitors Related | IKK 16 | PFE-360 | URMC-099 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | GNE-7915 | EB-42486 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Autophagy Compound Library | Multi-Target Compound Library | Neuroprotective Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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