D-64131 NEW
| Price | $29 | $43 | $95 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: D-64131 | CAS No.: 74588-78-6 |
| Purity: 99.48% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | D-64131 |
| Description | D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. |
| In vitro | D-64131 dose-dependently inhibited the polymerization of bovine brain microtubulin and the binding of [3H]colchicine to biotinylated αβ-microtubulin. After treatment with D-64131, many Y cells displayed abnormal microtubule structures, such as divided mitotic spindles or multiple spindle poles. Nuclear vesicles and abnormal nuclear structures typical of apoptotic cells were detected in many cells treated with D-64131. |
| In vivo | D-64131 dose-dependently inhibited the polymerization of bovine brain microtubulin and the binding of [3H]colchicine to biotinylated αβ-microtubulin. After treatment with D-64131, many Y cells displayed abnormal microtubule structures, such as divided mitotic spindles or multiple spindle poles. Nuclear vesicles and abnormal nuclear structures typical of apoptotic cells were detected in many cells treated with D-64131. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25.1 mg/mL (99.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.96 mM), Sonication is recommended. |
| Keywords | tubulin-inhibitory | Tubulin polymerization | phase | MicrotubuleAssociated | Microtubule/Tubulin | Microtubule Associated | Inhibitor | inhibit | G2/M | D-64131 | D64131 | D 64131 | cytotoxicity | carcinoma | astrocytoma | antiproliferative | antimitotic | activity |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Oxfendazole | Thiabendazole | Methylene Blue | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin | Albendazole |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | ReFRAME Related Library | Microtubule-Targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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