Dehydro Lacidipine NEW

Product Information

Product Number: L049005

English Name: Dehydro Lacidipine

English Alias: (E)-diethyl 4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

CAS Number: 130996-24-6

Molecular Formula: C₂₆H₃₁NO₆

Molecular Weight: 453.53

Analyzing the by-product formation mechanism of dehydration reactions or double bond formation during lacidipine synthesis to optimize processes for controlling olefin impurity generation;

Serving as a reference standard containing double bonds and ester groups to provide a standard substance for detecting unsaturated structure impurities in drugs, improving detection accuracy;

Helping study the impact of double bond configuration (E-type) on drug stability and activity to provide a scientific basis for impurity control strategies.

Applications

Drug Development: Used as an impurity reference standard to identify and quantify Dehydro Lacidipine in lacidipine preparations, evaluating the purity of APIs and formulations;

Quality Control: Acting as a standard substance to validate the sensitivity of detection methods (e.g., HPLC or LC-MS), ensuring dehydro impurity content meets pharmacopoeia requirements during production;

Stability Studies: Simulating dehydration or oxidation pathways under drug storage conditions to assist in establishing storage conditions and shelf life.

Background Description

Research Status

Synthesis Process: Developing high-purity synthesis methods for (E)-type double bond impurities to solve the cis-trans isomer separation challenge in olefin compound purification;

Detection Technologies: Establishing highly sensitive detection methods for this impurity, especially for double bond configuration identification, using reverse-phase HPLC combined with UV detectors or mass spectrometry;

Toxicological Evaluation: Studying the impact of double bond structures on potential drug toxicity through in vitro cell experiments;

Process Control: Analyzing the influence of parameters such as dehydration reaction temperature and reducing agent type on impurity generation to optimize conditions for reducing its content.