DO-264 NEW
| Price | $52 | $123 | $198 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: DO-264 | CAS No.: 2301866-59-9 |
| Purity: 99.20% | Supply Ability: 10g |
| Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | DO-264 |
| Description | DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis. |
| In vitro | DO-264 elevated the lyso-PS and 20:4 PS content of primary human macrophages[1]. |
| In vivo | Mice treated with DO-264 exhibited a dose-dependent increase in brain lyso-PS and 20:4 PS content, which qualitatively resembled changes observed in ABHD12(-/-) mice. Additionally, both ABHD12(-/-) and DO-264-treated mice displayed exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death.[1]. |
| Storage | Store under nitrogen,Store at low temperature, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 155 mg/mL (277.58 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (17.91 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (17.91 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | DO-264 | DO264 | DO 264 | ABHD12 |
| Inhibitors Related | MJN110 | AM6701 | JZL 184 | KML29 | ABX-1431 | JJKK 048 | JZP-361 | KT182 | JNJ-42226314 | WWL123 | KT203 | MAGL-IN-5 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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