Product Details
| Product Name:
Dupilumab |
CAS No.:
1190264-60-8 |
| Purity:
98.00% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | Dupilumab |
| Description | Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the alpha subunit of the interleukin-4 receptor, thereby inhibiting IL-4 and IL-13 signaling. As a systemic immunomodulator, it has demonstrated efficacy in improving atopic dermatitis. |
| In vitro | Dupilumab inhibited mRNA expression of T cells, dc, eosinophils, inflammatory pathways and Th2-induced chemokine activation related genes in skin lesions, and showed no activity against IL-17A and significantly decreased IL-22 levels, but 300 mg Dupilumab significantly decreased the expression of IL-17-related genes. Such as elafin (PI3), IL23p19/IL23A and S100A8, and have inhibitory potential (CXCL1 and S100A7). Dupilumab (300 mg) inhibited hyperproliferation-related genes, such as K16, and decreased the expression of S100A, as measured by microarray and qRT-PCR.[1] |
| In vivo | In human whole blood, dupilumab inhibits IL-4 and il-13 to stimulate thymus secretion and activates chemokine/chemokine C motif ligand 17 (TARC/CCL17). (Clinical biomarker for atopic dermatitis) with yarnamore potency (50% inhibition at 0.24 to 0.52 nM and 0.26 to 0.27 nM).[1] |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SAR231893 | SAR 231893 | REGN668 | REGN 668 | ILReceptor | IL-4 | IL-13 | IL Receptor | Dupilumab |
| Inhibitors Related | Disulfiram | Sodium Thiocyanate | Inosine pranobex | Ethyl palmitate | Amlexanox | Theophylline monohydrate | Balsalazide disodium dihydrate | 1,8-Cineole | Dexamethasone acetate | L-Arginine | Dexamethasone | Diallyl disulfide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$239.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-11-10 |
United States