Eicosapentaenoic Acid NEW
| Price | $68 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-02 |
Product Details
| Product Name: Eicosapentaenoic Acid | CAS No.: 10417-94-4 |
| Purity: 97.14% | Supply Ability: 10g |
| Release date: 2025/11/02 |
Product Introduction
Bioactivity
| Name | Eicosapentaenoic Acid |
| Description | Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation. |
| In vitro | METHODS: HepG2 cells were treated with Eicosapentaenoic Acid (0, 0.1, 0.2, 0.3, 0.4, 0.5 mM) for 12 hours, and the inhibitory effect on cell growth was detected by the MTT assay. RESULTS: Eicosapentaenoic Acid inhibited the growth of HepG2 cells (IC50=50 µM). [1] METHODS: N2a cells were treated with Eicosapentaenoic Acid (1.5 µM-200 µM). The fluorescence intensity of fluorescin was measured by 485 nm excitation and 528 nm emission using a microplate reader to quantify the number of viable cells. RESULTS: Eicosapentaenoic Acid at 25 µM was considered to have no significant effect on cell viability and was used in subsequent cell protection experiments, indicating that its toxicity to cells was relatively low at this concentration. [2] |
| In vivo | METHODS: To study the protective effect of Eicosapentaenoic Acid on the cardiovascular system, a diet rich in Eicosapentaenoic Acid was fed to spontaneously hypertensive rats (SHRs) for 20 weeks. RESULTS: Rats in the Eicosapentaenoic Acid diet group showed a reduction in interstitial cardiac fibrosis and an improvement in left ventricular diastolic function, despite persistently elevated blood pressure. The Eicosapentaenoic Acid diet increased the mRNA expression of M2-type macrophage marker Mrc1 and anti-inflammatory cytokine interleukin-10 (IL-10) in cardiac tissue. It indicates that the anti-fibrotic effect of EPA is partially achieved by promoting the polarization of macrophages to the anti-inflammatory M2 type and increasing IL-10. [3] METHODS: To study the antiviral efficacy of Eicosapentaenoic Acid, Eicosapentaenoic Acid (10, 50, and 100 mg/kg) was orally administered to C57 mice for 2 consecutive days. RESULTS: There was no significant difference in the serum ALT and urine CRE levels of mice in the Eicosapentaenoic Acid administration group compared with the control group, indicating that EPA had no hepatotoxicity or nephrotoxicity to mice at the given dose. HE staining also showed that EPA did not cause tissue damage in the liver and kidney tissues of mice. [4] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (330.63 mM), Sonication is recommended. Ethanol : 50 mg/mL (165.32 mM), Sonication is recommended. |
| Keywords | Timnodonic acid | RAS | long-chain polyunsaturated fatty acid | Inhibitor | inhibit | H-Ras intron 1 CpG island | HistoneDemethylase | Histone Demethylase | ERKC/EBPβ | EPA | EndogenousMetabolite | Endogenous Metabolite | Eicosapentaenoic Acid | DNA demethylating | CCAAT | C/EBPδ |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oxalic acid |
| Related Compound Libraries | Marine Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | FDA-Approved Drug Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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