Febuxostat sodium NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Febuxostat sodium | CAS No.: 1140907-13-6 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Febuxostat sodium |
| Description | Febuxostat (TEI 6720) sodium has the potential in gout and hyperuricemia research which is a potent, selective and non-purine inhibitor of xanthine oxidase (XO) with a Ki value of 0.6 nM [1] [2] [3]. |
| In vitro | Febuxostat sodium exhibits potent mixed-type inhibition against purified bovine milk xanthine oxidase, demonstrating inhibitory effects on both the oxidized and reduced forms of the enzyme, as evidenced by K i and K i ' values of 0.6 nM and 3.1 nM, respectively [1]. |
| In vivo | Febuxostat sodium, at varying dosages and treatment durations, has been observed to significantly mitigate adverse conditions in several experimental models. Administered daily at 5-6 mg/kg for 4 weeks to rats on a high-fructose diet (60% fructose) for 8 weeks, it substantially lowers glomerular pressure, renal vasoconstriction, and the afferent arteriolar area as compared to rats on the same diet without febuxostat, yet it does not affect rats on a standard diet [2]. A lower dose (3-4 mg/kg, orally) combined with oxonic acid (750 mg/kg, orally) for 4 weeks effectively prevents renal injury in 5/6 nephrectomy rats, with or without hyperuricemia [3]. Additionally, at 2.5 mg/kg taken orally for 12 weeks, it inhibits plaque formation in ApoE / mice and reduces ROS levels in the aortic walls of these atherosclerotic mice [4]. A higher dose (15.6 mg/kg, orally, once daily for 21 consecutive days) displays an antidepressant effect by significantly reducing immobility time in the Forced Swim Test in mice [5]. Moreover, when combined with doxorubicin at 10 mg/kg, orally, for 21 days, it greatly decreases nephrotoxicity markers and inflammatory mediators, restores normal oxidative stress biomarker values, and reduces renal caspase-3 expression [6]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Allopurinol | Phytic acid dodecasodium salt hydrate | Febuxostat | Benzbromarone | Phytic acid | Baicalein | Xanthine oxidoreductase-IN-5 | Tigulixostat | 4-Hydroxyacetophenone | Oxypurinol | Xanthine oxidoreductase-IN-4 | Xanthine oxidase-IN-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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