Product Details
| Product Name:
FK706 |
CAS No.:
144055-55-0 |
| Supply Ability:
10g |
Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | FK706 |
| Description | FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect. |
| In vitro | FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) (IC50: 230 nM) [1]. It blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and inhibits NF-κB activation. FK706 may directly block human lung fibroblasts activation of NF-κB, preventing the expression of inflammatory chemokines during cigarette smoke-induced lung inflammation [2]. |
| In vivo | Subcutaneous injection of FK706 (10-100 mg/kg; 1-6 hours; male C57BL mice) significantly inhibits human neutrophil elastase (20 μg/paw)-induced paw edema in a dose-dependent manner (47% inhibition at 100 mg/kg) [1]. |
| Storage | Keep away from moisture,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SerineProtease | Serine Protease | Porcine pancreatic elastase | Mouse neutrophil elastase | Human neutrophil elastase | FK-706 | FK706 | FK 706 |
| Inhibitors Related | PMSF | AEBSF hydrochloride | Imidazole | Subtilisin | Safflower oil (from Carthamus tinctorius seed) | p-Aminobenzamidine dihydrochloride | Chymotrypsin | Proteinase K | Ac-Ala-OH | Trypsin | FOY 251 | Chlorobenzothiazolinone |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
-
-
CAS:1858204-23-5
$2500.00
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States