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Postion:Product Catalog >API>Antipyretic analgesics>Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)>Flufenamic acid
Flufenamic acid
  • Flufenamic acid

Flufenamic acid NEW

Price $33 $47 $60
Package 50mg 100mg 200mg
Supply Ability: 10g
Update Time: 2026-05-30

Product Details

Product Name: Flufenamic acid CAS No.: 530-78-9
Purity: 99.71% Supply Ability: 10g
Release date: 2026/05/30

Product Introduction

Bioactivity

NameFlufenamic acid
DescriptionFlufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
In vivoUnder peak amyloid fibril formation conditions (pH 4.4), Flufenamic acid binds to wild-type transthyretin (KD1=30 nM, KD2=255 nM), V30M transthyretin (KD1=41 nM, KD2=320 nM), and L55P transthyretin (KD1=74 nM, KD2=682 nM) with high affinity and negative cooperativity (pH value 7.6), fully inhibiting fibril formation at a concentration of 10.8 μM. In Xenopus oocytes, Flufenamic acid reversibly suppresses ICl(Ca) in a dose-dependent manner, with an IC50 of 28 mM, without affecting the shape of the current-voltage curve in response to depolarizing voltage. Flufenamic acid inhibits the calcium-activated non-selective cation channels in the basolateral membrane of rat pancreatic exocrine cells activated by an inward-outward patch with an IC50 of 10 μM. The compound also inhibits currents activated by intracellular ADP-ribose in recombinant human TRPM2 (hTRPM2) channels and the CRI-G1 rat insulinoma cell line. Additionally, it reversibly inhibits (IC50=13.8 μM) DAP and phase discharge in rat suprachiasmatic neurons with similar kinetics, without significantly affecting membrane potential, spike threshold, or input resistance (P > 0.05), nor does it significantly affect the frequency and amplitude of spontaneous synaptic potentials.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationEthanol : 28.1 mg/mL (99.92 mM), Sonication is recommended.
10% DMSO+90% Saline : < 10 mg/mL (35.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 250 mg/mL (888.95 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (35.56 mM), Suspension.
KeywordsPotassiumChannel | Potassium Channel | Parasite | KcsA | Inhibitor | inhibit | Flufenamic acid | Cyclooxygenase | COX | Cl? Channels | Chloridechannel | Chloride Channel | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | AMPK | AMP-activated protein kinase
Inhibitors Related2,4,6-Tri-tert-butylphenol | Gum arabic | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | 1,8-Cineole | Fenpyroximate | Magnesium acetate tetrahydrate | Trometamol | Chitosan oligosaccharide | Magnesium Chloride Hexahydrate
Related Compound LibrariesAnti-Parasitic Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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