Galantamine hydrobromide NEW

Galantamine hydrobromide

Modify Date: 2024-01-02 08:10:43

Galantamine hydrobromide structure	Common Name	Galantamine hydrobromide
	CAS Number	1953-04-4	Molecular Weight	368.266
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C17H22BrNO3	Melting Point	256 °C
	MSDS	ChineseUSA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Purity		Quantity		Budget		Inquiry

Use of Galantamine hydrobromide Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

• Properties

• Articles40

• Spectrum

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 Names

Name	Galanthamine hydrobromide
Synonym	More Synonyms

 Galantamine hydrobromide Biological Activity

Description	Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. IC50 Value: 410 nM Target: AChEGalanthamine hydrobromide prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease
References	[1]. Kita Y, Ago Y, Takano E, Fukada A, Takuma K, Matsuda T.Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice.Psychopharmacology (Berl). 2012 Aug 30. [2]. Berkov S, Viladomat F, Codina C, Suárez S, Ravelo A, Bastida J.GC-MS of amaryllidaceous galanthamine-type alkaloids.J Mass Spectrom. 2012 Aug;47(8):1065-73. [3]. Park CW, Son DD, Kim JY, Oh TO, Ha JM, Rhee YS, Park ES.Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.Int J Pharm. 2012 Oct 15;436(1-2):32-40. Epub 2012 Jul 5. [4]. Park YS, Kim SH, Kim SY, Kim YH, Lee MH, Yang SC, Shaw LM, Kang JS.Quantification of Galantamine in Human Plasma by Validated Liquid Chromatography-Tandem Mass Spectrometry using Glimepride as an Internal Standard: Application to Bioavailability Studies in 32 Healthy Korean Subjects.J Chromatogr Sci. 2012 Jun 28. [5]. Arias et al Galantamine prevents apoptosis induced by b-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology (2004) 46 103.

 Chemical & Physical Properties

Melting Point	256 °C
Molecular Formula	C17H22BrNO3
Molecular Weight	368.266
Exact Mass	367.078308
PSA	41.93000
LogP	2.74630
Vapour Pressure	0mmHg at 25°C
Index of Refraction	-95 ° (C=1.4, H2O)
Storage condition	−20°C

 MSDS

Galantamine hydrobromide MSDS(Chinese)

 Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	R25:Toxic if swallowed.
Safety Phrases	45-36/37/39-22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DF8075000

 Synthetic Route

Previous 1/4 Next

Galanthaminone 510-77-0 ~10% Galantamine hyd... 1953-04-4

Literature: Kueenburg, Bernhard; Czollner, Laszlo; Frohlich, Johannes; Jordis, Ulrich Organic Process Research and Development, 1999 , vol. 3, # 6 p. 425 - 431

Galanthaminone 510-77-0 ~0% Galantamine hyd... 1953-04-4 Epi-galantamine 1668-85-5

Literature: Trinadhachari, Ganala Naga; Kamat, Anand Gopalkrishna; Raghu Babu, Korupolu; Sanasi, Paul Douglas; Prabahar, Koilpillai Joseph Tetrahedron Asymmetry, 2014 , vol. 25, # 2 p. 117 - 124

Galantamine 357-70-0 ~85% Galantamine hyd... 1953-04-4

Literature: Aurobindo Pharma Limited Patent: EP2009015 A1, 2008 ; Location in patent: Page/Page column 11; 12 ;

 Precursor & DownStream

Precursor  8	Previous 1/2 Next
CAS#:510-77-0 Galanthaminone  CAS#:357-70-0 Galantamine  CAS#:807362-55-6 (-)-galantamine...  CAS#:122584-18-3 N-(p-Hydroxyphe...
DownStream  3
CAS#:60755-80-8 O-Desmethyl gal...  CAS#:41303-74-6 N-Desmethyl Gal...  CAS#:357-70-0 Galantamine

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