Gepotidacin NEW
| Price | $364 | $1490 | $1940 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Gepotidacin | CAS No.: 1075236-89-3 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Gepotidacin |
| Description | Gepotidacin is a novel triazaacenaphthylene inhibitor of bacterial type II topoisomerase. |
| In vitro | Gepotidacin has in vitro activity against causative pathogens of acute bacterial skin and skin structure infections (ABSSSIs) [3]. Gepotidacin that inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated in vitro activity against gram-negative and gram-positive bacterias, including drug-resistant strains, and also targets pathogens associated with other conventional and biothreat infections. The MIC50 and MIC90 for gepotidacin against the 25 N. Gonorrhoeae isolate tested are 0.12 and 0.25 μg/mL, respectively [1]. The gepotidacin MIC90s are as follows: Streptococcus pyogenes (0.25 μg/mL); Escherichia coli (2 μg/mL); Moraxella catarrhalis (≤0.06 μg/mL); Streptococcus pneumoniae (0.25 μg/mL); Haemophilus influenzae (1 μg/mL); Clostridium perfringens (0.5 μg/mL); and Shigella spp. (1 μg/mL) [2]. |
| In vivo | ELF penetration ratios vary between 1.1 and 1.4. GSK2140944 exhibits minimum inhibitory concentrations (MICs) of 0.125 to 0.5 mg/L against six MRSA isolates. The average area under the curve (AUC)/MIC ratios necessary for bacterial stasis and a decrease of 1 log-unit are 59.3 ± 34.6 and 148.4 ± 83.3, respectively. The maximal reductions observed amount to 1.1 to 3.1 log10 CFU in neutropenic mice [4]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 7.14 mg/mL (15.92 mM), Sonication is recommended. |
| Keywords | Gepotidacin | GSK 2140944 | GSK-2140944 |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Ampicillin sodium | Acetic Acid | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Doxycycline | Trisodium Phosphate | BES |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd
|
2025-08-05 | |
| $0.00/1g |
VIP2Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2025-09-09 | |
| $108.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-10-26 | |
| $10.00/1ASSAYS |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2025-08-20 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY