Glycochenodeoxycholic Acid NEW
| Price | $2 |
| Package | 25kg |
| Min. Order: | 1kg |
| Supply Ability: | 1000000 |
| Update Time: | 2025-06-11 |
Product Details
| Product Name: Glycochenodeoxycholic Acid | CAS No.: 640-79-9 |
| Min. Order: 1kg | Purity: 99.99 |
| Supply Ability: 1000000 | Release date: 2025/06/11 |
Chemical Properties
| Boiling point | 655.6±40.0 °C(Predicted) |
| Density | 1.162±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 29 mg/mL (64.50 mM) |
| pka | 3.58±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | GHCZAUBVMUEKKP-VHGKAQQHNA-N |
| SMILES | C(O)(=O)CNC(=O)CC[C@@H](C)[C@@H]1[C@]2(CCC3[C@]4(C)[C@]([H])(C[C@@H](O)C3C2CC1)C[C@H](O)CC4)C |&1:9,11,12,16,18,21,28,r| |
Usage And Synthesis
Uses
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].
Definition
ChEBI: A bile acid glycine conjugate having 3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl as the bile acid component.
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. DOI:10.1016/j.toxlet.2020.05.017
[2] Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. DOI:10.1016/j.jceh.2017.04.002
[3] Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. DOI:10.1023/a:1007021710825
[4] Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. DOI:10.18632/aging.103751
[2] Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. DOI:10.1016/j.jceh.2017.04.002
[3] Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. DOI:10.1023/a:1007021710825
[4] Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. DOI:10.18632/aging.103751
Company Profile Introduction
Anhuyan (Hainan) Biotechnology Co., LTD, factory was founded in 2014 and has been engaged in the research and development and production of fine chemical raw materials and chemical reagents for a long time. The company has strong technical strength. Its products sell well all over the country and are exported abroad. It is deeply trusted by users and is rated as a high-tech enterprise in Hubei province.
After years of development, it has now formed a variety of product series, biological buffer series; Amino acid and amino acid derivatives series; Natural cosmetic raw material Series; Chemical reagent series; Pharmaceutical and chemical raw materials and intermediates, etc. We are committed to the development of high-quality products, which have been widely used in daily chemicals, food additives, textile additives, lubricating oil, resin, pesticide, medicine and chemical industry and other industries. Products include: Condo, CAPS,TRIS, dehydrorosin, polypropylene amine hydrochloride, 5,6-dihydroxyindole, chromium acetylpyruvate, tetraacetyl ribose, phosphomolybdic acid, molybdenum acid, 4-aminoantipyrine, dihydrochalcone, dithiosulfontanol (DTT),5-isoquinoline sulfonic acid, 6-benzylaminopyrine, isopropylate, camphoroquinone, silk fibroin, docurate sodium, etc. New loyalty customers are welcome to come for consultation and purchase.
Our company was renamed Hubei Yiling biotechnology LTD in 2014. It is a comprehensive high-tech modern enterprise integrating research and development, production and sales. Its sales company and research and development center are located in Guanggu biological City Medical Park, Wuhan city, Hubei Province. The company covers an area of 66279.6 sqm and has 2 production bases and 2 modern scientific research centers. The company has the international leading technical level, and has a group of professional scientific research personnel engaged in this industry. The academic leaders have a doctor's degree or above and have many years of
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $41.00/100mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-05-21 | |
| $0.00/1g |
VIP5Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-12-16 | |
| $94.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-04-27 | |
| $30.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-06-10 | |
| $0.00/1kg |
VIP1Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2025-04-21 |
China
INQUIRY