Product Details
| Product Name: Glycyrrhetinic acid | CAS No.: 471-53-4 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2025/10/13 |
| Lead time: in stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer, advantage products |
| COA, MSDS: Available, contact us for details | Contact: Tina |
PRODUCT INFORMATION
| Name | Enoxolone |
|---|---|
| Synonym | More Synonyms |
| Description | 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. |
|---|---|
| Related Catalog | Research Areas >> Cancer Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides |
| Target | Human Endogenous Metabolite |
| In Vitro | 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties. MTS assay demonstrates that 24 h treatment of 18β-Glycyrrhetinic acid suppresses cell proliferation in both cell lines in a dose-dependent manner. 18β-Glycyrrhetinic acid at 160 μM significantly decreases the percentage of viable cells to around 40.5±10.5% in A549 and 38.3±4.6% in NCI-H460 (p<0.01 respectively). When the cells are treated with 320 μM 18β-Glycyrrhetinic acid, a greater inhibitory effects on cell proliferation is shown, as the percentage of viable cells is below 30% compare with untreated controls (p<0.001). Treatment with 18β-Glycyrrhetinic acid at 160 μM and 320 μM decreases the levels of full-length PARP and increases the levels of cleaved-PARP[1]. |
| In Vivo | Rats in 18β-Glycyrrhetinic acid+Triptolide (TP) group which receive low-dose 18β-Glycyrrhetinic acid (50 mg/kg) have significant reductions in the three serum parameters when compare with TP rats. Rats in 18β-Glycyrrhetinic acid+TP group which receive the high-dose 18β-Glycyrrhetinic acid (100 mg/kg) have slightly lowered the levels of three liver enzymes, the reductions do not reach statistical significance compare with TP group. Contrastingly, preadministration of low-dose 18β-Glycyrrhetinic acid protects animals from TP-induced hepatic lesions. On the contrary, low-dose 18β-Glycyrrhetinic acid (50 mg/kg) markedly suppresses the release of the four cytokines above[3]. |
| Cell Assay | Primary microglia cultures are used in this study. For treatment assay, microglia are incubated with complete DMEM and stimulated with or without 100 ng/mL IFN-γ in the presence or absence of 18β-Glycyrrhetinic acid (25 μM and 50 μM) at 37°C in a humidified incubator with 5% CO2. For cell migration assay, the isolated primary microglia that seeded in complete DMEM medium are stimulated with or without IFN-γ (100 ng/mL), and treated with different doses of 18β-Glycyrrhetinic acid, 24 h later, the microglia culture supernatants are collected and added to the lower chambers of Transwell inserts[2]. |
| Animal Admin | Healthy Wistar rats (male, 200±20 g) are used and divided into five groups with 10 individuals for each group randomly. Animals in normal control (NC) group receive distilled water for 6 days and 0.5% CMC-Na for the last 3 days. Rats in Triptolide model group (TP), 18β-Glycyrrhetinic acid low-dose group (GAL+TP), and 18β-Glycyrrhetinic acid high-dose group (GAH+TP) receive distilled water, 18β-Glycyrrhetinic acid (50 mg/kg, p.o., dissolved in distilled water), or 18β-Glycyrrhetinic acid (100 mg/kg, p.o., dissolved in distilled water) for consecutive 6 days, respectively, and liver injury is induced by TP (2.4 mg/kg, p.o., suspended in 0.5% CMC-Na) for the last 3 days. Animals in the above three groups receive TP 6 hours after distilled water or 18β-Glycyrrhetinic acid treatment on the last 3 days[3]. |
| References | [1]. Huang RY, et al. 18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer. PLoS One. 2014 Apr 2;9(4):e93690. [2]. Zhou J, et al. 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. Sci Rep. 2015 Sep 2;5:13713. [3]. Yang G, et al. Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats. Evid Based Complement Alternat Med. 2017;2017:3470320. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.3±50.0 °C at 760 mmHg |
| Melting Point | 292 - 295ºC |
| Molecular Formula | C30H46O4 |
| Molecular Weight | 470.684 |
| Flash Point | 323.7±26.6 °C |
| Exact Mass | 470.339600 |
| PSA | 74.60000 |
| LogP | 6.57 |
| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
| Index of Refraction | 1.563 |
Glycyrrhetinic acid MSDS(Chinese) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |  GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R36 |
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RK0180000 |
| HS Code | 2938909030 |
 18α-Glycy... 83896-44-0 ~68%  α-D-Gluco... 6556-12-3  Glycyrrhetinic ... 471-53-4  N/A 6894-46-8 |
| Literature: Baltina; Flekhter; Putieva; Kondratenko; Krasnova; Tolstikov Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 4 p. 263 - 266 |
18α-Glycy... 83896-44-0 ~47% α-D-Gluco... 6556-12-3 Glycyrrhetinic ... 471-53-4 |
| Literature: Baltina; Flekhter; Putieva; Kondratenko; Krasnova; Tolstikov Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 4 p. 263 - 266 |
 6',6'&#... 87918-97-6 ~67% Glycyrrhetinic ... 471-53-4 |
| Literature: Kanaoka, Matao; Yano, Saburo; Kato, Hiromi; Nakano, Naoko; Kinoshita, Eiko Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 6 p. 1866 - 1873 |
| Precursor 8 | Previous 1/2 Next |
|---|---|
| |
| DownStream 6 | Previous 1/2 Next |
| |
CAS#:1405-86-3
CAS#:53956-04-0
CAS#:34096-83-8
CAS#:102416-29-5
CAS#:102416-28-4
CAS#:13832-70-7| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
Our Company
Our Advantage
Rich experience
Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
Excellent quality, purity, and competitive price
Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
Safe and fast delivery
We will arrange shipment of spot products as soon as we receive payment.
Customized products are determined based on the synthesis time of different products.
Excellent pre-sales and after-sales service
Pre sales:
We are committed to providing the most favorable quotes and detailed information about our products and company.
after-sale service:
We assist buyers in customs clearance by providing necessary documents and information.
If there is any dispute over product quality, we are committed to providing the best solution.
• Packaging:
1kg/bag, 25kg/drum, 50kg/drum, 180kg/drum, 200kg/drum, 1T/bag/drum, standard export packaging or packaging required by customers
• Shipping
• Delivery:
Within 7 days after receiving your payment
Contact information
For more details, pls contact us freely.
Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 15225627621
Company Profile Introduction
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $50.00/5g |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-10-28 | |
| $50.00/5g |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-10-27 | |
| $1200.00/1ton |
VIP1Y
|
Lianyungang Kaiyu Environmental Tech Co., Ltd.
|
2025-09-29 | |
| $0.00/1KG |
VIP2Y
|
Anhuyan (Hainan) Biotechnology Co., LTD
|
2025-06-10 | |
| $5.00/1KG |
VIP1Y
|
Wuhan JiyunZen Tech Co., Ltd.
|
2025-05-08 | |
| $/ |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2025-04-29 | |
| $43.00/500mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-04-28 | |
| $79.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co Ltd
|
2024-11-18 | |
| $0.00/1KG |
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-10-25 | ||
| $5.70/1KG |
VIP5Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-21 |
China