GSK3-IN-3 NEW
| Price | $34 | $79 | $139 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-15 |
Product Details
| Product Name: GSK3-IN-3 | CAS No.: 331963-27-0 |
| Purity: 99.37% | Supply Ability: 10g |
| Release date: 2025/05/15 |
Product Introduction
Bioactivity
| Name | GSK3-IN-3 |
| Description | GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective against 6-OHDA. |
| In vitro | GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells, but with limited potency.[1] GSK3-IN-3 (1.56-25 μM; 24 h) causes mitochondrial fission and mitochondrial morphological changes in U2OS-iMLS-Parkin cells.[1] GSK3-IN-3 (VP0.7) (5 μM, 10 μM) showed neuroprotective effects against 6-OHDA in an in vitro cellular model of Parkinson's disease in SH-SY5Y cells.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.8 mg/mL (8.7 mM), Sonication and heating to 60℃ are recommended. |
| Keywords | Mitophagy | GSK-3 | GSK3 |
| Inhibitors Related | Kaempferol | 5-Aminolevulinic acid hydrochloride | Resveratrol | Valproic Acid | Curcumin | Dexamethasone | Naringin | Metformin hydrochloride | Salicylic acid | Olaparib | Quercetin | Etoposide |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Neuroprotective Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Prostate Cancer Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Wnt/Hedgehog/Notch Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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