Hexamidine diisethionate

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Cosmetic Material Hexamidine Diisethionate/Factory supply

Hexamidine diisethionate: A broad-spectrum water-soluble cationic antimicrobial agent effective against bacteria, fungi, and yeast. It can serve as a multifunctional preservative and skin disinfectant, gaining increasing application in the cosmetics industry due to its excellent anti-acne, oil control, anti-irritation, and anti-dandruff properties.

INCI Name: Hexamidine diisethionate  

CAS Number: 659-40-5  

Molecular Formula: C24 H38 N4 O10 S2  

Molecular Weight: 606.72  

Regulatory Status: Approved for use in the USA, EU, Australia, Canada, and China.

Antimicrobial Properties:  

Hexamidine exhibits strong antimicrobial and bactericidal activity against:  

1. Gram-positive bacteria: Staphylococcus, Micrococcus, Streptococcus, Bacillus, Propionibacterium, and Clostridium.  

2. Gram-negative bacteria: Escherichia coli, Proteus, Klebsiella, Salmonella, Serratia, and Pseudomonas.  

3. Fungi: Aspergillus, Penicillium, Actinobacteria, Rhizopus, and Trichophyton.  

4. Yeasts: Malassezia and Pityrosporum.

The antimicrobial activity of hexamidine diisethionate varies under different conditions:  

1. Concentration and contact time of the antimicrobial agent.  

2. Number of microorganisms.  

3. Nature and virulence of the microorganisms.  

4. Characteristics of the growth medium.

Cosmetic Applications:  

Hexamidine diisethionate is suitable for incorporation into cosmetics and hygiene products such as emulsions, masks, gels, aqueous solutions, alcoholic solutions, foam formulations, and sprays.  

1. Microbial inhibition (preservative): It is recommended that each cosmetic formulation be studied individually.  

2. Skin and hair disinfectant, for instance: care for oily and/or acne-prone skin, due to its antimicrobial activity against specific strains like Propionibacterium acnes; it can inhibit the lipase activity of Propionibacterium acnes; has indirect anti-irritation effects (slowing down triglyceride hydrolysis from sebaceous glands); anti-dandruff care (effective against Malassezia); and in deodorant products.