Product Details
| Product Name:
HQ461 |
CAS No.:
1226443-41-9 |
| Purity:
98.11% |
Supply Ability:
10g |
| Release date:
2025/08/21 |
Product Introduction
Bioactivity
| Name | HQ461 |
| Description | HQ461 is a molecular glue that promotes CDK12-DDB1 interaction, triggering cyclin K degradation, decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 62 mg/mL (179.48 mM), Sonication and heating to 60℃ are recommended.
|
| Keywords | MolecularGlues | Molecular Glues | molecular glue | Inhibitor | inhibit | HQ-461 | HQ461 | HQ 461 | DNA damage | cyclin K degrader | Cyclin dependent kinase | CDK12 substrate phosphorylation | CDK12 | CDK |
| Inhibitors Related | Ribociclib | PT-179 | Abemaciclib | Thalidomide | Palbociclib monohydrochloride | Pomalidomide | Lenalidomide | CASIN | Palbociclib | GW 441756 | Dinaciclib | Abemaciclib methanesulfonate |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States