IDO1-IN-2 NEW
| Price | $1520 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: IDO1-IN-2 | CAS No.: 2346614-58-0 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | IDO1-IN-2 |
| Description | IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. |
| In vitro | IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood.IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. |
| In vivo | IDO1-IN-2 exhibits pharmacokinetic properties with a half-life (t1/2) of 3.7 hours, a clearance/bioavailable unbound clearance (CL/CLu) of 15/319 mL/min/kg, and bioavailability (F) of 63% in rats. In dogs, its half-life extends to 6 hours, with a CL/CLu of 6/88 mL/min/kg, and a bioavailability of 67%. Furthermore, IDO1-IN-2, administered at a dose of 100 mg/kg twice daily, effectively enhances therapeutic outcomes when used alongside anti-PD-1 monoclonal antibodies (mAb) in a mouse EMT6 tumor syngeneic model, demonstrating significant synergy in efficacy. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | IDO1-IN-2 | IDO-1-IN-2 | IDO1IN2 | IDO1 IN 2 | IDO1 |
| Inhibitors Related | Kushenol E | GNF-PF-3777 | Linrodostat | LY3381916 | BMS-986242 | IDO1-IN-1 | PF-06840003 | Epacadostat | β-Lapachone | IDO5L | IDO-IN-12 | IDO-IN-13 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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