Product Details
| Product Name:
iMDK |
CAS No.:
881970-80-5 |
| Purity:
99.99% |
Supply Ability:
10g |
| Release date:
2026/03/13 |
Product Introduction
Bioactivity
| Name | iMDK |
| Description | iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice. |
| In vitro | Administration of iMDK (50-500 nM) for 72 h quarterhydrate suppressed AKT phosphorylation in H441 lung adenocarcinoma cells after treatment dose-dependently. In contrast, iMDK quarterhydrate robustly increases p-ERK[1]. |
| In vivo | Intraperitoneally injection with 100 μl of iMDK ( (9 mg/kg/day) and ; oral administion of PD0325901 (5 mg/kg) effectively reduced lung tumor growth in a xenograft mouse model[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.77 mg/mL (10.02 mM), Sonication is recommended.
|
| Keywords | PI3K | Phosphoinositide 3-kinase | NSCLC | midkine | MDK | Inhibitor | inhibit | iMDK | growth | factor |
| Inhibitors Related | Musk ketone | Myricetin | Creatine monohydrate | Erucic acid | Hyaluronic acid | 4-Methylbenzylidene camphor | Berberine hydrogen sulphate | Isoprenaline hydrochloride | Methyl eugenol | Thymoquinone | Heptadecanoic acid | Berberine sulfate |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Autophagy Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States