IRAK inhibitor 4 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: IRAK inhibitor 4 | CAS No.: 1012104-68-5 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | IRAK inhibitor 4 |
| Description | IRAK inhibitor 4 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). |
| In vitro | IRAK1/4, at a concentration of 20 μM, suppresses LPS-induced IL-6 production but does not affect p38 phosphorylation in alveolar macrophages (AMs). Concurrently, the use of both IRAK1/4 and Rip2 inhibitors significantly reduces TLR2-mediated cytokine production in sarcoidosis patient-derived peripheral blood mononuclear cells (PBMCs) and AMs. Moreover, IRAK4 is found to be both overexpressed and activated in T-cell acute lymphoblastic leukemia (T-ALL), with IRAK4 mRNA levels being higher in T-ALL cells from patients compared to those in thymic T cells or peripheral blood T cells. Additionally, the absence of IRAK-4 compromises the ability of macrophages and dendritic cells (DCs) to produce pro-inflammatory mediators in response to M. bovis and M. tuberculosis. IRAK-4-deficient cells, when stimulated with E. coli LPS, show significantly slower activation kinetics across all signaling proteins examined and a marked decrease in p65 phosphorylation. |
| In vivo | IRAK-4-/- mice demonstrate an elevated bacterial load across all organs at 15, 30, and 60 days post-infection. Moreover, MCL1, unlike BCL-xL, negates the therapeutic benefits of combined IRAK1/4 inhibitor and ABT-737 treatment in vivo. Additionally, these mice experience significantly decreased survival rates after aerosol infection compared to their IRAK-4+/+ or IRAK-4+/- counterparts. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 12.5 mg/mL (20.14 mM), Sonication is recommended. |
| Keywords | IRAK inhibitor 4 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $87.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-10-26 | |
| $143.00/2mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-10-27 | |
| $2.00/100kg |
VIP1Y
|
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
|
2025-06-19 | |
| $2500.00/100mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-10-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY