JAK-IN-1 NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: JAK-IN-1 | CAS No.: 1334673-53-8 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | JAK-IN-1 |
| Description | JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. |
| In vitro | JAK-IN-1 exhibits both mechanistic and functional activity in cell-based assays involving T-cells, a primary cell type where JAK3 has potential relevance. It effectively inhibits the proliferation of human CD4 and CD8 T cells in a dose-dependent fashion when stimulated by anti-CD3/anti-CD28 antibody-coated beads, which partially simulate the activation signals delivered to a T cell by an antigen-presenting cell. |
| In vivo | JAK-IN-1 effectively inhibits IL-2-induced STAT5 phosphorylation in both a dose- and concentration-dependent fashion, achieving roughly 50% reduction at a dose of 10 mg/kg (plasma concentration approximately 480 nM). Demonstrating selectivity for JAK3 in vivo, JAK-IN-1 exhibits greater efficacy in inhibiting JAK1/JAK3-driven signaling compared to pathways involving JAK2 or the combination of JAK1, JAK2, and TYK2, as evaluated through whole blood assays. Additionally, JAK-IN-1 strongly suppresses IL-2 stimulated plasma concentrations corresponding to each administered dose. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | JAK-IN-1 | JAKIN1 | JAK3 | JAK2 | JAK1 | JAK IN 1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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