Product Details
| Product Name:
JC124 |
CAS No.:
1638611-48-9 |
| Purity:
99.64% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | JC124 |
| Description | JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities. |
| In vitro | JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1]. |
| In vivo | In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (13.06 mM), Sonication is recommended.
DMSO : 225.0 mg/mL (587.7 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.
|
| Keywords | NLRP3 | JC124 |
| Inhibitors Related | Stavudine | Ascorbyl palmitate | Trimethylamine N-oxide | MCC950 sodium | β-Aminoarteether | Imperatorin | Muscone | NLRP3-IN-2 | Bergenin | Troxerutin | Articaine hydrochloride | ADS032 |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States