Product Details
| Product Name:
Karenitecin |
CAS No.:
203923-89-1 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | Karenitecin |
| Description | Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity. |
| In vitro | Karenitecin, a topoisomerase I inhibitor, exhibits potent anti-cancer properties by effectively inhibiting the growth of various human colon cancer cell lines, including COLO205, COLO320, LS174T, SW1398, and WiDr, demonstrated by IC50 values of 2.4 nM, 1.5 nM, 1.6 nM, 2.9 nM, and 3.2 nM, respectively[2]. Furthermore, it not only induces DNA damage in A253 cells at concentrations of 0.01, 0.07, and 0.7 μM but also elevates the levels of cyclin E and cdk2 proteins at 0.07 and 0.7 μM. Significant cell growth inhibition in A253 cells is achieved with IC10, IC50, and IC90 values of 0.01, 0.07, and 0.7 μM after a 2-hour treatment. Additionally, at low concentrations, Karenitecin significantly augments cyclin B/cdc2-associated kinase activity, whereas it slightly diminishes this activity at higher concentrations[1]. |
| In vivo | Karenitecin (1.0 mg/kg daily × 5 i.p.) significantly reduces growth in both parental Pgp-negative xenografts and Pgp-positive xenografts[2]. It demonstrates a maximum growth inhibition of 61% in COLO320 cells and 54% in COLO205 colon cancer cells following i.p. administration at a dosage of 1 mg/kg in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Topoisomerase I | Karenitecin | BNP-1350 | BNP1350 |
| Inhibitors Related | Berberine chloride | EIDD-1931 | Flumequine | Levofloxacin hydrochloride | Norfloxacin | Prulifloxacin | Enoxacin | Pefloxacin Mesylate | Ciprofloxacin | Ciprofloxacin monohydrochloride | Irinotecan hydrochloride trihydrate | Etoposide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States