KDOAM-25 NEW
| Price | $1619 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: KDOAM-25 | CAS No.: 2230731-99-2 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | KDOAM-25 |
| Description | KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at transcriptional start sites and reduces proliferation in multiple myeloma MM1S cells. |
| In vitro | KDOAM-25 treatment induces G1 cell-cycle arrest, characterized by an increased MM1S cell proportion in G1 phase and a decreased proportion in G2 phase, without affecting apoptotic sub-G1 phase cell counts. At a concentration of 50 μM, KDOAM-25 doubles the level of H3K4me3 in multiple myeloma cells, demonstrating strong inhibition of KDM5B at an IC50 of approximately 50 μM, while inhibiting other KDM5 family members at concentrations exceeding 100 μM. Furthermore, KDOAM-25 exhibits no activity against other JmjC family proteins and reduces MM1S cell viability with an IC50 of approximately 30 μM, manifesting effects after a 5-7 day period. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | KDOAM-25 | KDOAM25 | KDOAM 25 | KDM5D | KDM5C | KDM5B | KDM5A |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Ampicillin sodium | Acetic Acid | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Doxycycline | Trisodium Phosphate | BES |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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