Product Details
| Product Name:
KHK-IN-1 hydrochloride |
CAS No.:
1303470-48-5 |
| Purity:
98.05% |
Supply Ability:
10g |
| Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | KHK-IN-1 hydrochloride |
| Description | KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity. |
| In vitro | Methods: HepG2 cells were treated with KHK-IN-1 hydrochloride (0-10 µM) and the level of KHK product F1P in cell lysates was measured using LC-MS quantification of F1P
Results: KHK-IN-1 hydrochloride inhibited the production of F1P in HepG2 cell lysates with an IC50 value of 400 nM.[1] |
| In vivo | Methods: Rats were treated with KHK-IN-1 hydrochloride (10 mg/kg, oral) for pharmacokinetic studies.
Results: KHK-IN-1 hydrochloride showed reasonable oral bioavailability in rats (F = 34%; oral t1/2 = 4 h); high distribution volume (Vdss = 32 L/kg) and high clearance (CL = 160 mL/min/kg); its plasma Cmax was only 0.16 μM.[2] |
| Storage | keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (43.57 mM), Sonication is recommended.
H2O : 10 mg/mL (21.79 mM), Sonication is recommended.
|
| Keywords | KHK-IN-1 Hydrochloride | KHKIN1 hydrochloride | KHK IN 1 hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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