KM 11060 NEW

KM 11060

Modify Date: 2024-01-24 17:48:34

KM 11060 structure	Common Name	KM 11060
	CAS Number	774549-97-2	Molecular Weight	422.328
	Density	1.5±0.1 g/cm3	Boiling Point	607.3±65.0 °C at 760 mmHg
	Molecular Formula	C19H17Cl2N3O2S	Melting Point	N/A
	MSDS	ChineseUSA	Flash Point	321.1±34.3 °C
	Symbol	GHS06	Signal Word	Danger

Purity		Quantity		Budget		Inquiry

Use of KM 11060 KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

• Properties

• Articles1

• Spectrum

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 Names

Name	7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
Synonym	More Synonyms

 KM 11060 Biological Activity

Description	KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Endocrinology
References	[1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. [2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.

 Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	607.3±65.0 °C at 760 mmHg
Molecular Formula	C19H17Cl2N3O2S
Molecular Weight	422.328
Flash Point	321.1±34.3 °C
Exact Mass	421.041840
PSA	61.89000
LogP	4.19
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.676
Storage condition	2-8℃

 MSDS

KM 11060 MSDS(Chinese)

 Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
RIDADR	UN 2811 6.1 / PGIII
HS Code	2935009090

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     Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. 

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