Product Details
| Product Name:
Kobe2602 |
CAS No.:
454453-49-7 |
| Purity:
98.36% |
Supply Ability:
10g |
| Release date:
2025/10/23 |
Product Introduction
Bioactivity
| Name | Kobe2602 |
| Description | Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. |
| Kinase Assay | Migration assays: Assays are conducted in wells of a 24-well, 8 μm pore size Transwell plate. A 6.5-mm insert membrane is coated with 0.1 mL COL-I (300 μg/mL in MEGM) and then air dried for 16 hours. The collagen coating is rehydrated for 1 hour in 0.2 mL MEGM. The inner chamber contains MEGM-10% FBS as a chemoattractant. The compounds (10–100 μmol/L) or DMSO (0.1%–1%) are added to both inner and outer chambers. Before plating in the outer chamber, cells (5×104) are coincubated for 20 minutes with the compounds or DMSO in MEGM. Cells are allowed to migrate for 16 to 18 hours. The cells remaining on the top surface of the membrane are removed with a cotton swab. The cells on the bottom surface of the membrane are fixed and stained (0.2% crystal violet). The incorporated dye is extracted with 1% SDS and the A570 is measured. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (119.24 mM), Sonication is recommended.
|
| Keywords | Ras-Raf | Ras | Raf | Kobe-2602 | Kobe2602 | Kobe 2602 | Inhibitor | inhibit | H-Ras | carcinoma | antiproliferative |
| Inhibitors Related | Adagrasib | BI-2493 | Regorafenib monohydrate | RMC-9805 | Sorafenib | Ketoconazole | MRTX1133 | RMC-6236 | Regorafenib | Dabrafenib | Sorafenib tosylate | N-Acetylneuraminic acid |
| Related Compound Libraries | Ferroptosis Compound Library | Anti-Pancreatic Cancer Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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$1.00/1ASSAYS |
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