KU-177 NEW
| Price | $2130 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-16 |
Product Details
| Product Name: KU-177 | CAS No.: 1160952-43-1 |
| Purity: 98.54% | Supply Ability: 10g |
| Release date: 2025/09/16 |
Product Introduction
Bioactivity
| Name | KU-177 |
| Description | KU-177 is a Hsp90 ATPase homolog 1 (Aha1) inhibitor. By disrupting the interaction between Hsp90 and Aha1, it prevents the proliferation of primary MM and relapsed MM patient samples. It eliminates the proliferation and PI resistance induced by AHSA1 elevation. |
| In vitro | KU-177 (50 μM, 48 hours of action) was able to inhibit the proliferation of flow MRD-positive cells in samples from patients with primary and relapsed multiple myeloma (MM). [1] In AHSA1 WT/OE cells, PSMD2 WT/OE cells and ANBL6 WT/DR cells, KU-177 (30 μM, treated for 48 hours) decreased proteasome activity. [1] KU-177 disrupts the interaction of Aha1 with Hsp90 with an IC50 value of 4.08 μM without affecting the ATPase activity of Hsp90. [2] KU-177 (25 μM, incubated at 37°C for 30 min) inhibits the aggregation of recombinant P301L tau protein but does not affect the refolding of fluorokinase by inhibiting Hsp90. [2] KU-177 (10 μM, treated for 24 hours) exhibits the ability to disrupt the interaction of Aha1 with Hsp90 in SH-SY5Y neuroblastoma cells and SK-BR-3 breast cancer cells, while not significantly inhibiting the Hsp90 client protein Her2. [2] |
| In vivo | In the 5TMM3VT multiple myeloma mouse model, KU-177 (1 mg/kg, intraperitoneal injection twice weekly for 4 weeks) was able to inhibit tumor growth and prolong survival without showing significant toxicity. When combined with Bortezomib (1 mg/kg, intraperitoneal injection), KU-177 demonstrated more significant therapeutic effects in vivo. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Ethoxyquin | SNX0723 | Tamoxifen | SNX2112 | Ganetespib | Teprenone | Elesclomol | Rifabutin | Palmitic acid | Paeoniflorin | Tamoxifen Citrate | 17-AEP-GA |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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