LDN193189 Tetrahydrochloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: LDN193189 Tetrahydrochloride | CAS No.: 2310134-98-4 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | LDN193189 Tetrahydrochloride |
| Description | LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia. |
| In vitro | LDN-193189 Tetrahydrochloride potently inhibits the kinase activity of ALK4 and ActRIIA with IC50 values of 101 and 210 nM, respectively.[2] |
| In vivo | Methods: SCID mice bearing MDA-PCa-118b tumor xenografts were treated with LDN-193189 Tetrahydrochloride (3 mg/kg, intraperitoneal injection, twice daily). Tumor size and body weight were measured weekly to investigate the effect of LDN-193189 Tetrahydrochloride on tumor growth in vivo. Results: Treatment of MDA-PCa-118b tumor-bearing mice with LDN-193189 Tetrahydrochloride resulted in decreased bone formation and attenuated tumor growth. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 25 mg/mL (45.26 mM), Sonication is recommended. DMSO : 3.3 mg/mL (5.97 mM), Sonication is recommended. |
| Inhibitors Related | Lorlatinib | SB-431542 | DMH-1 | Hydrochlorothiazide | Crizotinib | Chromenone 1 | Ceritinib | Dorsomorphin | Pirfenidone | A 83-01 | Alantolactone | Oxymatrine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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