Leachianone A NEW
| Price | $73 | $197 | $318 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-02 |
Product Details
| Product Name: Leachianone A | CAS No.: 97938-31-3 |
| Purity: 98.53% | Supply Ability: 10g |
| Release date: 2025/11/02 |
Product Introduction
Bioactivity
| Name | Leachianone A |
| Description | Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. |
| In vitro | In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1] |
| In vivo | Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1]. |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 75 mg/mL (171.03 mM), Sonication is recommended. |
| Keywords | SGLT | Leachianone A | Inhibitor | inhibit | Apoptosis |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Tributyrin | L-Methionine | Sodium citrate | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Polyphenolic Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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