Loxapine hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Loxapine hydrochloride | CAS No.: 54810-23-0 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Loxapine hydrochloride |
| Description | Loxapine hydrochloride is a dibenzoxazepine anti-psychotic agent that exerts its effects through oral administration, functioning as an inhibitor of dopamine and an antagonist of 5-HT receptors [1] [4]. |
| In vitro | Loxapine, when present, facilitates the binding of [3 H]ketanserin to the 5-HT2 receptor in the frontal cortex of both human and bovine brains, with K_i values of 6.2 nM and 6.6 nM, respectively. The potency hierarchy of Loxapine across various receptors is indicated as 5-HT2 ≥ D4 >>> D1 > D2, based on competition experiments with human membranes [1]. Additionally, Loxapine at concentrations ranging from 0-20 μM over periods of 24 h or 72 h, notably decreases IL-1β and IL-2 secretion in mixed glia and LPS-induced microglia cultures, demonstrating its immunomodulatory effects [2]. |
| In vivo | Loxapine, administered at a dosage of 5 mg/kg via intraperitoneal injection daily for 4 or 10 weeks, significantly reduces the density of serotonin (S2) receptors by more than 50% in adult male Wistar rats (150-175 g) without causing an increase in dopamine (D2) receptor numbers in the rat brain [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Trifluoperazine dihydrochloride | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Octopamine hydrochloride | 1,8-Cineole | Citicoline | Oxolinic acid | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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