LUF7244 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: LUF7244 | CAS No.: 1821638-43-0 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | LUF7244 |
| Description | LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1]. |
| In vitro | LUF7244, at concentrations ranging from 0 to 10 μM, specifically targets and binds to Kv11.1 channels in HEK293 cells, thereby enhancing the IKv11.1 by preventing its inactivation in a dose-responsive manner [1]. In cardiomyocytes within the same concentration range, LUF7244 significantly shortens the action potential duration (APD) by about 50% and mitigates dofetilide-induced early afterdepolarizations (EAD) in isolated ventricular cardiomyocytes from both SR and CAVB dogs [1]. At a concentration of 10 μM, LUF7244 does not affect the currents I_KIR2.1, I_Nav1.5, I_Ca-L, and I_Ks, but it notably increases I_Kr twofold [1]. |
| In vivo | LUF7244, administered intravenously at a dosage of 2.5 mg/kg over 15 minutes, effectively reduces repolarization parameters and exhibits antiarrhythmic properties, mitigating dofetilide-induced Torsades de Pointes (TdP) arrhythmias in dogs with chronic atrioventricular block (CAVB) [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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