Malformin A NEW

Malformin A

Modify Date: 2024-01-12 09:02:28

Malformin A structure	Common Name	Malformin A
	CAS Number	3022-92-2	Molecular Weight	529.71600
	Density	1.123 g/cm3	Boiling Point	921ºC at 760 mmHg
	Molecular Formula	C23H39N5O5S2	Melting Point	N/A
	MSDS	N/A	Flash Point	510.8ºC

Purity		Quantity		Budget		Inquiry

Use of Malformin A Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].

• Properties

• Spectrum

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 Names

Name	10-butan-2-yl-7-(2-methylpropyl)-4-propan-2-yl-15,16-dithia-3,6,9,12,18-pentazabicyclo[11.4.2]nonadecane-2,5,8,11,19-pentone
Synonym	More Synonyms

 Malformin A Biological Activity

Description	Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Sun-Young Park, et al. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. Int J Oncol. 2017 Sep;51(3):959-966.

 Chemical & Physical Properties

Density	1.123 g/cm3
Boiling Point	921ºC at 760 mmHg
Molecular Formula	C23H39N5O5S2
Molecular Weight	529.71600
Flash Point	510.8ºC
Exact Mass	529.23900
PSA	196.10000
LogP	2.21120
Index of Refraction	1.497
Storage condition	-20°C

 Toxicological Information

CHEMICAL IDENTIFICATION RTECS NUMBER : ON7050000 CHEMICAL NAME : Malformin A CAS REGISTRY NUMBER : 3022-92-2 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H39-N5-O5-S2 MOLECULAR WEIGHT : 529.79 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3100 ug/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 39,1325,1975

 Safety Information

Hazard Codes	T+
Risk Phrases	23/24/25
Safety Phrases	36/37/39-45

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