Product Details
| Product Name:
Manitimus |
CAS No.:
202057-76-9 |
| Purity:
99.75% |
Supply Ability:
10g |
| Release date:
2025/09/11 |
Product Introduction
Bioactivity
| Name | Manitimus |
| Description | Manitimus (FK778) is an inhibitor of dehydroorotate dehydrogenase and an immunosuppressant with immunosuppressive and antiproliferative activity, prevents vascular remodeling after mechanical endothelial injury, and can be used to study immune dysfunction. |
| In vivo | Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts[2].In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg)[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Manitimus | FK-778 | FK 778 | Dehydroorotate dehydrogenase |
| Inhibitors Related | Methotrexate | Mycophenolate Mofetil | 18β-Glycyrrhetinic acid | Ribavirin | 4-Diethylaminobenzaldehyde | Methotrexate disodium | 2-Methylaminoethanol | Benzyl alcohol | 2-Bromoacetamide | Isomalt | Sodium Oxamate | 6-Mercaptopurine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$197.00/1mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-10-27 |
United States