Metallo-β-lactamase-IN-9 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: Metallo-β-lactamase-IN-9 | CAS No.: 1802363-75-2 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | Metallo-β-lactamase-IN-9 |
| Description | Metallo-β-lactamase-IN-9 (Compound 23) is a broad-spectrum inhibitor of metallo-beta-lactamases (MBL), with inhibition constants (IC50) of 35 nM for NDM-1, 269 nM for VIM-1, and 369 nM for IMP-1 [1]. |
| In vivo | Metallo-β-lactamase-IN-9 (Compound 23), co-administered with Imipenem at doses of 10 and 50 mg/kg and injected subcutaneously three times daily, effectively reduced bacterial load in the spleens and kidneys of mice in a Klebsiella pneumoniae MB9249 infection model [1]. Pharmacokinetic analysis in mice showed that a single intravenous dose (1 mg/kg) produced an AUC of 27.08 μM·h, MRT of 5.2 hours, Vdss of 2.97 L/kg, and Cl of 9.33 mL/min/kg. Subcutaneous administration resulted in an AUC of 27.42 μM·h at 10 mg/kg and 111.28 μM·h at 50 mg/kg, with Cmax values of 13.4 μM and 69.1 μM and Tmax of 0.83 and 0.5 hours, respectively. Formulations included Compound 23 at 1.0 mg/mL in 20% DMSO/60% PEG400/20% water for intravenous delivery (5 mL/kg) and at 1.0 mg/mL or 5.0 mg/mL in 30% captisol for subcutaneous injection (10 mL/kg) [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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