Product Details
| Product Name:
MI-3454 |
CAS No.:
2134169-43-8 |
| Purity:
99.68% |
Supply Ability:
10g |
| Release date:
2025/09/16 |
Product Introduction
Bioactivity
| Name | MI-3454 |
| Description | MI-3454 is an orally active, selective and potent inhibitor of Menin-MLL1 interaction that inhibits the proliferation and induces differentiation of acute leukemia cells with MLL1 translocation or NPM1 mutation.MI-3454 induces complete remission or regression of leukemia in a mouse model of leukemia with MLL1 rearrangement or NPM1 mutation through the down-regulation of key genes involved in leukemogenesis. complete remission or remission. |
| In vitro | In murine bone marrow cells transformed with MLL-AF9 or Hoxa9/Meis1, MI-3454 (0.001, 0.01, 0.1, 1, 10 μM; 7 days) demonstrated a significant reduction in cell proliferation[1]. |
| In vivo | In 8- to 10-week-old female NSG mice (MV-4-11 xenotransplantation model of MLL leukemia), MI-3454 (120 mg/kg; orally; once or twice daily for 7 consecutive days) is sufficient to block leukemia progression[1]. |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (31.41 mM), Sonication is recommended.
|
| Keywords | MI-3454 | MI3454 | MI 3454 | Menin-MLL | HistoneMethyltransferase | Histone Methyltransferase |
| Inhibitors Related | MAK-683 hydrochloride | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | MAK683 | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$2780.00/50mg |
VIP2Y
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TargetMol Chemicals Inc.
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2025-08-21 |
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$3598.00/25mg |
VIP4Y
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TargetMol Chemicals Inc.
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2025-08-21 |
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$0.00/1mg |
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Hubei Chuchang Biotech Co., Ltd.
|
2024-03-28 |
United States