Product Details
| Product Name:
Miclxin |
CAS No.:
2494198-61-5 |
| Purity:
99.94% |
Supply Ability:
10g |
| Release date:
2025/09/19 |
Product Introduction
Bioactivity
| Name | Miclxin |
| Description | Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60. |
| In vitro | Miclxin (0-15 μM; 48 h) inhibits growth in both β-catenin mutant HCT116 cells and isogenic HCT116 cells (CTNNB1 Δ45/-), and at (10 μM; 24 h) induces apoptosis in HCT116 cells.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (113.25 mM), Sonication is recommended.
|
| Keywords | β-catenin | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | Miclxin | DS-37262926 | DS 37262926 | beta-catenin | betacatenin | bcatenin |
| Inhibitors Related | Urea | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | CHIR-99021 | XAV-939 | HLY78 | Nefopam hydrochloride | KY-05009 | Methyl Vanillate | Bisdemethoxycurcumin |
| Related Compound Libraries | Apoptosis Compound Library | Osteogenesis Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Neuroprotective Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Active Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States