Product Details
| Product Name:
Mivotilate |
CAS No.:
130112-42-4 |
| Supply Ability:
10g |
Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | Mivotilate |
| Description | Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. |
| In vitro | Mivotilate has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate is a nontoxic and potent activator of the aryl hydrocarbon receptor. Mivotilate causes cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3]. |
| In vivo | Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats, and at doses of 75-300 mg/kg, it rapidly decreases immunoreactive CYP2E1 protein. Additionally, Mivotilate (150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats without significantly affecting NADPH-dependent P450 oxidoreductase activity [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | YH-439 | YH 439 | Mivotilate | Aryl hydrocarbon receptor |
| Inhibitors Related | Diosmin | Sudan IV | 2-Mercaptobenzothiazole | 5,6-Benzoflavone | Benzyl butyl phthalate | 1-Hydroxypyrene | Skatole | L-Kynurenine | Indole-3-carbinol | MeBIO | DiMNF | Dibenzothiophene |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States