Product Details
| Product Name:
MNF |
CAS No.:
145370-39-4 |
| Purity:
98.55% |
Supply Ability:
10g |
| Release date:
2026/07/31 |
Product Introduction
Bioactivity
| Name | MNF |
| Description | MNF is a specific aryl hydrocarbon receptor (AhR) antagonist that effectively inhibits TCDD-induced AhR signaling pathway activation, attenuates TCDD-induced activation of downstream signaling molecules Akt and Erk1/2 and TGFα expression, and reverses the anti-apoptotic effect of TCDD. It is commonly used in research on AhR-related functions and signaling pathways. |
| In vitro | MNF (0.1–1000 nM; 24 h) can inhibit TCDD-dependent DRE-driven luciferase activity in MCF-10A cells at concentrations as low as 10 nM [1].
MNF (0.1–1000 nM; 3 days) reverses the TCDD-dependent inhibition of apoptosis in MCF-10A cells, with significant effects observed at concentrations of 100 nM and 1000 nM [1].
MNF (0.1–1000 nM; 6 h) attenuates Akt phosphorylation levels in MCF-10A cells, with significant inhibition observed at 1 nM and complete inhibition achieved at 100 nM [1].
MNF (0.1–1000 nM; 6 h) reverses TCDD-mediated Erk1,2 phosphorylation in MCF-10A cells at concentrations of 10 nM and above; when acting alone, a concentration of 1 nM enhances basal Erk1,2 activation [1].
MNF (0.1–100 nM; 6 h) completely abolishes TCDD-dependent TGFα mRNA expression in MCF-10A cells at concentrations as low as 1 nM [1].
MNF (0.5–2.5 μM) potently inhibits the basal deethylation activity of ethoxyhalogenated compounds by recombinant human CYP1A1 [2].
MNF (0.05–2.5 μM; 1.5–20 h) dose-dependently inhibits 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced ethoxyhalogen deethylation activity in HaCaT cells in vitro [2].
MNF (0.05–2.5 μM; 1.5–48 h) initially inhibited and subsequently enhanced FICZ-dependent CYP1A1 mRNA expression and ethoxyhalogen deethylation activity in HaCaT cells, with a significant enhancing effect observed at prolonged incubation times [2].
MNF (0.05–2.5 μM; 0–40 h) induces aromatin receptor-dependent ethoxyquin deethylation activity in HaCaT cells; this effect is dependent on endogenous FICZ in the culture medium [2].
MNF (0.05 μM; 0–30 h) induces AR-dependent CYP1A1 mRNA expression in HaCaT cells, a process that requires FICZ present in commercial cell culture media [2].
MNF (50 nM; 48 h) induces ethoxyhalogen deethylation activity in HaCaT cells only in the presence of 0.1 pM FICZ [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NU-6310 | NU 6310 | MNF |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Ethyl linoleate | Formamide | Naringin | Gluconate Calcium | Alginic acid | Sildenafil citrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Anhui Ruihan Technology Co., Ltd
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