Product Details
| Product Name:
Mogamulizumab |
CAS No.:
1159266-37-1 |
| Purity:
99.4% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2025/10/09 |
Product Introduction
Bioactivity
| Name | Mogamulizumab |
| Description | Mogamulizumab (KW-0761) is a monoclonal antibody targeting T cell CC chemokine receptor 4. It exhibits anticancer activity by eliminating tumor cells through antibody-dependent cytotoxicity (ADCC) and can be used in the study of cancer, adult T-cell leukemia/lymphoma (ATLL), and cutaneous T-cell lymphoma (CTCL). |
| In vitro | In the presence of PBMCs, Mogamulizumab (10 μg/mL, 24 h) induces ADCC activity against CCR4-positive cell lines (SNT8, SNT16, SNK6, and KAI3)[2].
In PBMCs from patients with HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP), Mogamulizumab (10 μg/mL, 3 days) reduces the human T-lymphotropic virus type 1 (HTLV-1) proviral load and inhibits spontaneous proliferation[3].
Cultured PBMCs from patients with HAM/TSP treated with Mogamulizumab (1 μg/mL, 5 days) eliminate CD4+CCR4+ T cells[3]. |
| In vivo | In a murine xenograft model, Mogamulizumab (1 mg/kg, i.p., twice per week for 4 weeks) inhibits the growth of EBV-positive NK-cell lymphomas when combined with PBMC transplantation[2].
In a canine bladder cancer-engrafted mouse model, Mogamulizumab (0.1 mg/kg, i.v., every other day) combined with canine PBMCs (administered every fourth day) inhibits tumor growth[4].
Mogamulizumab (0.01-1 mg/kg, i.v.) reduces circulating CD4+CCR4+ T cells in dogs, with no observed adverse effects[4]. |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Mogamulizumab | KW0761 | KW 0761 | CXCR4 |
| Inhibitors Related | AZD8309 | AZD2098 | Tannic acid | Artemotil | Maraviroc | BMS-817399 | PF-4136309 | Pirfenidone | Vercirnon | Nicotinamide N-oxide | Plerixafor | CCR6 antagonist 1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States