Morinidazole Impurity 42(Iodide) NEW

Morinidazole Impurity 42(Iodide)

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com.

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• Product Information

• Product Number: M035042B

• English Name: Morinidazole Impurity 42(Iodide)

• English Alias: 1-ethyl-1-(2-hydroxy-3-morpholinopropyl)-2-methyl-5-nitro-1H-imidazol-1-ium iodide

• CAS Number: None

• Molecular Formula: C₁₃H₂₃N₄O₄·I

• Molecular Weight: 423.26（The molecular weight of C₁₃H₂₃N₄O₄ is approximately 343.35, plus the atomic weight of iodine 126.90）

• Advantages

• As an impurity reference standard (iodide form) for morinidazole, this compound has the following advantages:
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• Well-defined and Stable Structure: The clear chemical structure and stable iodide salt form facilitate the analysis of the by-product formation mechanism of alkylation, nitration, and salification reactions during morinidazole synthesis, optimizing the production process.

• Accurate Detection Standard: The special structure containing imidazole ring, morpholine group, nitro group, and iodide ion can provide an accurate standard for detection methods such as HPLC and LC-MS, improving the separation and quantification accuracy of complex impurities.

• Research Value of Characteristics: The iodide form endows it with unique physical and chemical properties, helping to study the stability of this impurity under different environments and its impact on the quality of morinidazole formulations, providing a basis for impurity control.

• Applications

• Drug Development: In the research and development of morinidazole and its formulations, it is used as an impurity reference standard to identify and quantify Morinidazole Impurity 42(Iodide), evaluating the purity of APIs and formulations.

• Quality Control: As a standard substance, it validates the sensitivity and specificity of detection methods such as HPLC and LC-MS, ensuring that the impurity content during production meets pharmacopoeia and regulatory requirements.

• Stability Studies: Investigating the degradation behavior of this impurity under light, high temperature, and high humidity conditions, evaluating its impact on the stability of morinidazole formulations, and assisting in determining storage conditions and shelf life.

• Background Description

• Morinidazole is a nitroimidazole antibacterial drug used for treating anaerobic infections. During its synthesis, due to multiple reaction steps and functional group transformations, various impurities are likely to be generated if the conditions are not properly controlled. Morinidazole Impurity 42(Iodide), as an iodide impurity, may affect the safety, effectiveness, and bioavailability of the drug. With the improvement of drug quality standards, the research and control of such impurities have become crucial for ensuring drug quality.

• Research Status

• Detection Method Optimization: Using advanced techniques such as ultra-high-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and high-resolution mass spectrometry (HRMS) to develop highly sensitive detection methods for trace detection of this impurity.

• Synthesis Process Improvement: Studying the formation pathway of the impurity and reducing its generation by optimizing reaction temperature, catalysts, and raw material ratios.

• Toxicological Evaluation: Assessing the potential toxicity of this impurity through in vitro cytotoxicity experiments and animal models to provide data for formulating impurity limit standards.

• Stability Investigation: Systematically studying its stability under different environmental factors, analyzing its impact on the quality of morinidazole formulations, and improving the drug quality control system

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com