Product Details
| Product Name: N-Succinimidyl maleimidoacetate | CAS No.: 55750-61-3 |
| Min. Order: 5g | Purity: 98.13% |
| Supply Ability: 10kg | Release date: 2025/12/01 |
Here's a concise summary of N-Succinimidyl maleimidoacetate (≤100 words):
Chemical Identity:
Heterobifunctional crosslinker (C₁₀H₈N₂O₆) combining:
NHS ester: Reacts with primary amines (-NH₂, e.g., lysine)
Maleimide: Binds thiols (-SH, e.g., cysteine) via Michael addition.
Key Features:
Spacer arm: Acetate bridge (spacing: ~7.7 Å).
Orthogonal reactivity: Enables controlled two-step bioconjugation.
Water-sensitive: NHS ester hydrolyzes rapidly (use anhydrous solvents).
Primary Use:
Creating stable conjugates:
Antibody-drug conjugates (ADCs)
Protein-protein/peptide complexes
Surface functionalization.
Handling: Store dry at -20°C; use immediately after dissolving in DMSO/DMF.
Avoid aqueous buffers during reaction!
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