NP-313 NEW
| Price | $48 | $122 | $197 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-17 |
Product Details
| Product Name: NP-313 | CAS No.: 5397-78-4 |
| Purity: 98.97% | Supply Ability: 10g |
| Release date: 2025/10/17 |
Product Introduction
Bioactivity
| Name | NP-313 |
| Description | NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
| In vitro | NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner, reducing thrombin- and A23187-induced aggregation by up to 80% and 60%, respectively.[1] At concentrations of 0-8 μM, NP-313 concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B2 (TXB2) production in human platelets, and inhibits COX-1 and TXA2 synthase with IC50 values of 1.5 and 3.9 μM, respectively.[1] |
| In vivo | NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (240.34 mM), Sonication is recommended. |
| Keywords | Thromboxane A2 synthetase | NP-313 | NP313 | CalciumChannel | Calcium Channel |
| Inhibitors Related | Nisoldipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | AEBSF hydrochloride | L-Phenylalanine | D-Menthol | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Nifedipine |
| Related Compound Libraries | Cysteine Covalent Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Calcium Channel Compound Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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