Nrf2-ARE/hMAO-B/QR2 modulator 1 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-09-18 |
Product Details
| Product Name: Nrf2-ARE/hMAO-B/QR2 modulator 1 | Supply Ability: 10g |
| Release date: 2025/09/18 |
Product Introduction
Bioactivity
| Name | Nrf2-ARE/hMAO-B/QR2 modulator 1 |
| Description | Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model. |
| In vitro | After incubating the ARE-blaHepG2 cell line with Nrf2-ARE/hMAO-B/QR2 modulator 1 for 16 hours, CCF4-AM substrate mixture was added, and fluorescence intensity was measured to assess the activity of the Nrf2-ARE pathway. The Results showed that at a concentration of 10μM, the expression of TuJ-1 and MAP-2 was highest, and the migration distance of mouse neural stem cells was also the greatest. The study indicates that Nrf2-ARE/hMAO-B/QR2 modulator 1 effectively activates the Nrf2-ARE pathway, inhibits hMAO-B and QR2, and demonstrates significant neuroprotective effects[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (195.11 mM), Sonication is recommended. |
| Inhibitors Related | TBHQ | Dimethyl fumarate | Metronidazole | Pyridoxine | Resveratrol | 1,4-Naphthoquinone | Curcumin | Paeonol | Hydroxylamine hydrochloride | NAD+ | 4-hydroxyphenylacetic acid | Apocynin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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