NSC59984 NEW
| Price | $64 | $109 | $228 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-22 |
Product Details
| Product Name: NSC59984 | CAS No.: 803647-40-7 |
| Purity: 99.59% | Supply Ability: 10g |
| Release date: 2025/10/22 |
Product Introduction
Bioactivity
| Name | NSC59984 |
| Description | NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. |
| Cell Research | Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference) |
| In vitro | NSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1] |
| In vivo | In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 49 mg/mL (184.72 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 55 mg/mL (207.34 mM), Sonication is recommended. |
| Keywords | p53 | NSC-59984 | NSC59984 | NSC 59984 | MDM-2/p53 | Inhibitor | inhibit |
| Inhibitors Related | 10-Hydroxydecanoic Acid | Flubendazole | PRIMA-1 | Rotenone | XI-006 | 2,5-Dihydroxybiphenyl | Thiabendazole | Minocycline hydrochloride | Triglycidyl isocyanurate | C16 Ceramide | Indole-3-carbinol | Diethanolamine hydrochloride |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Ubiquitination Compound Library | Glutamine Metabolism Compound Library | NO PAINS Compound Library | Metabolism Compound Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
![4-Chlorothieno[3,2-d]pyrimidine](https://img.chemicalbook.com/ProductImageEN1/2025-09/Large/776fdc41-3201-4752-ac53-453e7be75c5d.png)
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2019-12-23 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY